Mice Display Sex Differences in Halothane-induced Polymorphic Ventricular Tachycardia Mice Display Sex Differences in Halothane-induced Polymorphic Ventricular Tachycardia
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Milou-Daniel Drici, Linda Baker, Patricia Plan, Jacques Barhanin, Georges Romey and Guy Mice Display Sex Differences in Halothane-Induced Polymorphic Ventricular Tachycardia Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2002 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.0000023629.72479.24 2002;106:497-503; originally published online July 1, 2002; Circulation. http://circ.ahajournals.org/content/106/4/497 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Mice display sex differences in halothane-induced polymorphic ventricular tachycardia.
BACKGROUND Molecularly engineered mice are extensively used as models of cardiovascular diseases, yet little is known about sex differences in the electrophysiology of mouse hearts. METHODS AND RESULTS This study investigated the influence of sex on drug-induced polymorphic ventricular tachycardia (PVT) in Langendorff-perfused male and female mice hearts (n=54) by injecting a bolus of halotha...
متن کاملParadoxical Effect of Increased Diastolic Ca Release and Decreased Sinoatrial Node Activity in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia
Catecholaminergic polymorphic ventricular tachycardia is a congenital arrhythmogenic disease linked to -adrenergic–induced ventricular arrhythmias that has a high mortality in children and young adults when untreated. As common features of the catecholaminergic polymorphic ventricular tachycardia phenotype, supraventricular arrhythmias have also been described in catecholaminergic polymorphic v...
متن کاملShort communication: flecainide exerts an antiarrhythmic effect in a mouse model of catecholaminergic polymorphic ventricular tachycardia by increasing the threshold for triggered activity.
RATIONALE Flecainide prevents arrhythmias in catecholaminergic polymorphic ventricular tachycardia, but the antiarrhythmic mechanism remains unresolved. It is possible for flecainide to directly affect the cardiac ryanodine receptor (RyR2); however, an extracellular site of action is suggested because of the hydrophilic nature of flecainide. OBJECTIVE To investigate the mechanism for the anti...
متن کاملCalcium Leak Through Ryanodine Receptors Leads To Atrial Fibrillation In Three Mouse Models of Catecholaminergic Polymorphic Ventricular Tachycardia
Rationale: Atrial fibrillation (AF) is the most common cardiac arrhythmia, however the mechanism(s) causing AF remain poorly understood and therapy is suboptimal. The ryanodine receptor (RyR2) is the major calcium (Ca) release channel on the sarcoplasmic reticulum (SR) required for excitationcontraction coupling in cardiac muscle. Objective: In the present study we sought to determine whether i...
متن کاملCalcium leak through ryanodine receptors leads to atrial fibrillation in 3 mouse models of catecholaminergic polymorphic ventricular tachycardia.
RATIONALE Atrial fibrillation (AF) is the most common cardiac arrhythmia, however the mechanism(s) causing AF remain poorly understood and therapy is suboptimal. The ryanodine receptor (RyR2) is the major calcium (Ca2+) release channel on the sarcoplasmic reticulum (SR) required for excitation-contraction coupling in cardiac muscle. OBJECTIVE In the present study, we sought to determine wheth...
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تاریخ انتشار 2002